Developing New Generation Medicines for Depression and Other Central Nervous System (CNS) Diseases and Disorders

AV-101, our oral N-methyl-D-aspartate receptor glycine B (NMDAR GlyB) antagonist, belongs to a new generation of investigational medicines in neuropsychiatry known as glutamate receptor modulators having the potential to treat Major Depressive Disorder (MDD) faster than current FDA-approved antidepressants commonly known as SSRIs and SNRIs, which target the neurotransmitters serotonin and/or norepinephrine, respectively.

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Going Above and Beyond Current Treatment Options

Focused on providing novel solutions for millions of patients with depression and other CNS diseases and disorders.

About us

Committed to Developing a New Generation of Oral Antidepressants

AV-101, our oral N-methyl-D-aspartate receptor glycine B (NMDAR GlyB) antagonist, belongs to a new generation of investigational medicines in neuropsychiatry known as glutamate receptor modulators having the potential to treat depression, including Major Depressive Disorder (MDD), faster than current FDA-approved antidepressants commonly known as SSRIs and SNRIs, which target the neurotransmitters serotonin and/or norepinephrine, respectively. AV-101 is in Phase 2 development, initially for the adjunctive treatment of MDD. ELEVATE is our ongoing Phase 2, randomized, double-blind, multi-center, placebo-controlled clinical trial designed to evaluate the efficacy and safety of adjunctive use of oral AV-101 for MDD in patients with an inadequate response to standard antidepressant therapy with either an FDA-approved selective SSRI or SNRI.

What Makes AV-101 Different?

Going Above and Beyond Current Treatment Options

Focused on providing novel solutions for millions of depression patients with inadequate response to current FDA-approved antidepressants.

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Backed by an Experienced Leadership Team

Our highly experienced Management Team, Board of Directors, and CNS Clinical and Regulatory Advisory Board have a proven track record of developing innovative medicines to treat a wide range of CNS diseases and disorders.

Meet Our Team

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