PH10 Nasal Spray for Depression Disorders
PH10 is an investigational CNS pherine nasal spray with potential to be a fast-acting stand-alone treatment for neuropsychiatric indications involving depression. Developed from proprietary compounds called pherines and administered at microgram level doses as an odorless nasal spray, PH10 activates nasal chemosensory cells in the nasal passages, connected to neural circuits in the brain that produce antidepressant effects. Specifically, PH10 engages peripheral chemosensory receptors in the nasal passages that trigger a subset of neurons in the main OB that stimulate neurons in the limbic amygdala. This is turn increases activity of the limbic-hypothalamic sympathetic nervous system and increases the release of catecholamines.
PH10 was designed to not require systemic uptake and distribution to produce its rapid-onset antidepressant effects. In a small randomized, double-blind, placebo-controlled exploratory Phase 2A clinical study in major depressive disorder (MDD), at a 6.4 mcg dose, rapid-onset antidepressant effects were observed and sustained for 8 weeks (p=0.022), without psychological side effects or safety concerns associated with ketamine-based therapy. With its rapid-onset pharmacology, lack of systemic exposure at clinical doses administered to-date and favorable safety results observed in all clinical studies to date, we believe PH10 has potential to be a new stand-alone treatment for several depression disorders.