000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) link:calculationLink link:definitionLink link:presentationLink 006 - Disclosure - Note 1 - Description of Business link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 2 - Basis of Presentation and Going Concern link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 3 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 4 - Prepaid Expenses and Other Current Assets link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 5 - Property and Equipment link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 6 - Accrued Expenses link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 7 - Notes Payable link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 8 - Capital Stock link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 9 - Research and Development Expenses link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 10 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 11 - Licensing, Sublicensing and Collaborative Agreements link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 13 - Related Party Transactions link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 15 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 16 - Supplemental Financial Information (Unaudited) link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 3 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 4 - Prepaid Expenses and Other Current Assets (Tables) link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 5 - Property and Equipment (Tables) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 6 - Accrued Expenses (Tables) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 8 - Capital Stock (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 10 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 11 - Licensing, Sublicensing and Collaborative Agreements (Tables) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan (Tables) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications (Tables) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 16 - Supplemental Financial Information (Unaudited) (Tables) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 1 - Description of Business (Details Textual) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 2 - Basis of Presentation and Going Concern (Details Textual) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 3 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 3 - Summary of Significant Accounting Policies - Basic and Diluted Net Loss (Details) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 3 - Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Securities Excluded From Earnings Per Share Computation (Details) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 4 - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Details) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 5 - Property and Equipment - Schedule of Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note 5 - Property and Equipment - Depreciation and Amortization Expense (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 5 - Property and Equipment - Schedule of Assets Subject to Financing Lease (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 6 - Accrued Expenses - Schedule of Accrued Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 7 - Notes Payable (Details Textual) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 8 - Capital Stock (Details Textual) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 8 - Capital Stock - Schedule of Warrants (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 8 - Capital Stock - Reserves Shares (Details) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 9 - Research and Development Expenses (Details Textual) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 10 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 10 - Income Taxes - Income Tax Expense (Benefit) (Details) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 10 - Income Taxes - Deferred Tax Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 10 - Income Taxes - Uncertain Tax Positions (Details) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 11 - Licensing, Sublicensing and Collaborative Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 11 - Licensing, Sublicensing and Collaborative Agreements - Changes in Contract Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan - Consolidated Statement of Operations and Comprehensive Loss (Details) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan - Black-Scholes Option Pricing (Details) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan - Summary of Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note 12 - Stock Option Plans, Employee Stock Purchase Plan, and 401(k) Plan - Stock Option Outstanding and Exercisable (Details) link:calculationLink link:definitionLink link:presentationLink 059 - Disclosure - Note 13 - Related Party Transactions (Details Textual) link:calculationLink link:definitionLink link:presentationLink 060 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications (Details Textual) link:calculationLink link:definitionLink link:presentationLink 061 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications - Finance Lease Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 062 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications - Operating lease in Condensed Consolidated Balance Sheet (Details) link:calculationLink link:definitionLink link:presentationLink 063 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications - Operating Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 064 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications - Minimum Lease Payments (Details) link:calculationLink link:definitionLink link:presentationLink 065 - Disclosure - Note 14 - Commitments, Contingencies, Guarantees and Indemnifications - Operating Activities in Cash flow Statements (Details) link:calculationLink link:definitionLink link:presentationLink 066 - Disclosure - Note 15 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink 067 - Disclosure - Note 16 - Supplemental Financial Information (Unaudited) - Quarterly Results of Operations (Unaudited) (Details) link:calculationLink link:definitionLink link:presentationLink