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  <xs:element id="vtgn_JefferiesLLCMember" abstract="true" name="JefferiesLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_ATMFacilityMember" abstract="true" name="ATMFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_StockSalesAgreementMaximumAggregateOfferingPrice" abstract="false" name="StockSalesAgreementMaximumAggregateOfferingPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_StockSalesAgreementAdditionalAggregateOfferingPrice" abstract="false" name="StockSalesAgreementAdditionalAggregateOfferingPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_StockSalesAgreementCommissionOnSharesSoldPercentage" abstract="false" name="StockSalesAgreementCommissionOnSharesSoldPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="vtgn_StockSalesAgreementRemainingAmountAvailable" abstract="false" name="StockSalesAgreementRemainingAmountAvailable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_WarrantsExpiringDecember92024Member" abstract="true" name="WarrantsExpiringDecember92024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_WarrantsExpiringJuly252025Member" abstract="true" name="WarrantsExpiringJuly252025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_WarrantsWithExercisePriceOf0.001Member" abstract="true" name="WarrantsWithExercisePriceOf0.001Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_WarrantsWithExercisePriceOf5.380Member" abstract="true" name="WarrantsWithExercisePriceOf5.380Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_WarrantsExpiringOctober42028Member" abstract="true" name="WarrantsExpiringOctober42028Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_ClassOfWarrantOrRightWeightedAverageExercisePrice" abstract="false" name="ClassOfWarrantOrRightWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="vtgn_ClassOfWarrantOrRightOutstandingWarrantsSubjectToAntiDilutionProtectionFeature" abstract="false" name="ClassOfWarrantOrRightOutstandingWarrantsSubjectToAntiDilutionProtectionFeature" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vtgn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="vtgn_AmendedAndRestated2016StockIncentivePlanAndAmendedAndRestated2019OmnibusEquityIncentivePlanMember" abstract="true" name="AmendedAndRestated2016StockIncentivePlanAndAmendedAndRestated2019OmnibusEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementAffaMedAgreementMember" abstract="true" name="CollaborativeArrangementAffaMedAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_NegotiationAgreementMember" abstract="true" name="NegotiationAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_FujiPharmaMember" abstract="true" name="FujiPharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="vtgn_UpfrontLicensePayment" abstract="false" name="UpfrontLicensePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_RevenueRecognitionMilestoneMethodMaximumMilestonePaymentsPermitted" abstract="false" name="RevenueRecognitionMilestoneMethodMaximumMilestonePaymentsPermitted" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementTerminationPeriodOptionOne" abstract="false" name="CollaborativeArrangementTerminationPeriodOptionOne" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementTerminationPeriodOptionTwo" abstract="false" name="CollaborativeArrangementTerminationPeriodOptionTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementUpfrontPayment" abstract="false" name="CollaborativeArrangementUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_ContractWithCustomerAssetRollForward" abstract="true" name="ContractWithCustomerAssetRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="vtgn_ContractWithCustomerAssetIncreaseForAdditions" abstract="false" name="ContractWithCustomerAssetIncreaseForAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_ContractWithCustomerAssetDecreaseForDeductions" abstract="false" name="ContractWithCustomerAssetDecreaseForDeductions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_ContractWithCustomerLiabilitiesRollForward" abstract="true" name="ContractWithCustomerLiabilitiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="vtgn_ContractWithCustomerLiabilityIncreaseForAdditions" abstract="false" name="ContractWithCustomerLiabilityIncreaseForAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_ContractWithCustomerLiabilityDecreaseForDeductions" abstract="false" name="ContractWithCustomerLiabilityDecreaseForDeductions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_DotsonConsultingAgreementMember" abstract="true" name="DotsonConsultingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vtgn_FitzPatrickCo.LLCConsultingAgreementMember" abstract="true" name="FitzPatrickCo.LLCConsultingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vtgn_I3StrategyPartnersConsultingAgreementMember" abstract="true" name="I3StrategyPartnersConsultingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vtgn_ConsultingFeesInitialPayment" abstract="false" name="ConsultingFeesInitialPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_ConsultingFeesMonthlyPayment" abstract="false" name="ConsultingFeesMonthlyPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_SublicenseAndOtherRevenueMember" abstract="true" name="SublicenseAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
