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  <xs:element id="vtgn_CollaborativeArrangementTerminationPeriodOptionOne" abstract="false" name="CollaborativeArrangementTerminationPeriodOptionOne" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementTerminationPeriodOptionTwo" abstract="false" name="CollaborativeArrangementTerminationPeriodOptionTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vtgn_CollaborativeArrangementUpfrontPayment" abstract="false" name="CollaborativeArrangementUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vtgn_DotsonConsultingAgreementMember" abstract="true" name="DotsonConsultingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vtgn_SublicenseAndOtherRevenueMember" abstract="true" name="SublicenseAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
