0001 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 0002 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 0003 - Statement - CONDENSED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 0005 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 0006 - Statement - CONSOLIDATED STATEMENTS OF PREFERRED STOCK link:presentationLink link:calculationLink link:definitionLink 0007 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' DEFICIT link:presentationLink link:calculationLink link:definitionLink 0008 - Disclosure - Description of Business link:presentationLink link:calculationLink link:definitionLink 0009 - Disclosure - Basis of Presentation and Going Concern link:presentationLink link:calculationLink link:definitionLink 0010 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 0011 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 0012 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 0013 - Disclosure - AV-101 Acquisition link:presentationLink link:calculationLink link:definitionLink 0014 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 0015 - Disclosure - Convertible Promissory Notes and Other Notes Payable link:presentationLink link:calculationLink link:definitionLink 0016 - Disclosure - Capital Stock link:presentationLink link:calculationLink link:definitionLink 0017 - Disclosure - Research and Development Expenses link:presentationLink link:calculationLink link:definitionLink 0018 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0019 - Disclosure - Licensing and Collaborative Agreements link:presentationLink link:calculationLink link:definitionLink 0020 - Disclosure - Stock Option Plans and 401(k) Plan link:presentationLink link:calculationLink link:definitionLink 0021 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 0022 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications link:presentationLink link:calculationLink link:definitionLink 0023 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 0024 - Disclosure - Supplemental Financial Information link:presentationLink link:calculationLink link:definitionLink 0025 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 0026 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 0027 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 0028 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 0029 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 0030 - Disclosure - Convertible Promissory Notes and Other Notes Payable (Tables) link:presentationLink link:calculationLink link:definitionLink 0031 - Disclosure - Capital Stock (Tables) link:presentationLink link:calculationLink link:definitionLink 0032 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 0033 - Disclosure - Stock Option Plans and 401(k) Plan (Tables) link:presentationLink link:calculationLink link:definitionLink 0034 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications (Tables) link:presentationLink link:calculationLink link:definitionLink 0035 - Disclosure - Subsequent Events (Tables) link:presentationLink link:calculationLink link:definitionLink 0036 - Disclosure - Supplemental Financial Information (Tables) link:presentationLink link:calculationLink link:definitionLink 0037 - Disclosure - Description of Business (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0038 - Disclosure - Basis of Presentation and Going Concern (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0039 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 0040 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 0041 - Disclosure - Fair Value Measurements (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0042 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 0043 - Disclosure - AV-101 Acquisition (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0044 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 0045 - Disclosure - 7. Convertible Promissory Notes and Other Notes Payable (Details) link:presentationLink link:calculationLink link:definitionLink 0046 - Disclosure - 7. Convertible Promissory Notes and Other Notes Payable (Details 2) link:presentationLink link:calculationLink link:definitionLink 0047 - Disclosure - 7. Convertible Promissory Notes and Other Notes Payable (Details 1) link:presentationLink link:calculationLink link:definitionLink 0048 - Disclosure - 7. Convertible Promissory Notes and Other Notes Payable (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0049 - Disclosure - 7. Convertible Promissory Notes and Other Notes Payable (Details Textuals 2) link:presentationLink link:calculationLink link:definitionLink 0050 - Disclosure - 9. Capital Stock (Details) link:presentationLink link:calculationLink link:definitionLink 0051 - Disclosure - 9. Capital Stock (Details 1) link:presentationLink link:calculationLink link:definitionLink 0052 - Disclosure - Capital Stock (Details 2) link:presentationLink link:calculationLink link:definitionLink 0053 - Disclosure - 9. Capital Stock (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0054 - Disclosure - Research and Development Expenses (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 0055 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 0056 - Disclosure - Income Taxes (Details 1) link:presentationLink link:calculationLink link:definitionLink 0057 - Disclosure - Income Taxes (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 0058 - Disclosure - Stock Option Plans and 401(k) Plan (Details) link:presentationLink link:calculationLink link:definitionLink 0059 - Disclosure - Stock Option Plans and 401(k) Plan (Details 1) link:presentationLink link:calculationLink link:definitionLink 0060 - Disclosure - Related Party Transactions (Details Textuals) link:presentationLink link:calculationLink link:definitionLink 0061 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications (Details) link:presentationLink link:calculationLink link:definitionLink 0062 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications (Details 1) link:presentationLink link:calculationLink link:definitionLink 0063 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications (Details 2) link:presentationLink link:calculationLink link:definitionLink 0064 - Disclosure - Commitments, Contingencies, Guarantees and Indemnifications (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 0065 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink 0066 - Disclosure - Supplemental Financial Information (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 0067 - Disclosure - Supplemental Financial Information (Details) link:presentationLink link:calculationLink link:definitionLink