<XBRL>
<?xml version="1.0" encoding="utf-8" standalone="yes"?>
<!-- Compliance Xpressware Instance Document http://www.compliancexpressware.com/  -->
<!-- Version: 1.0.0 --><!-- Creation date:12:57:59 GMT-0800 -->
<!-- Copyright (c) Compliance Xpressware, LLP. All Rights Reserved. -->
<xsd:schema targetNamespace="http://www.vistagen.com/20111231" elementFormDefault="qualified" attributeFormDefault="unqualified" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:vsta="http://www.vistagen.com/20111231" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/DocumentAndEntityInformation" id="role_DocumentAndEntityInformation">
        <link:definition>101 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/BalanceSheet" id="role_BalanceSheet">
        <link:definition>103 - Statement - Statement of Financial Position</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/BalanceSheetParenthetical" id="role_BalanceSheetParenthetical">
        <link:definition>104 - Statement - Statement of Financial Position (Parenthetical)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/IncomeStatement" id="role_IncomeStatement">
        <link:definition>105 - Statement - Statement of Operations</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/CashFlows" id="role_CashFlows">
        <link:definition>108 - Statement - Statement of Cash Flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/StockholdersEquity" id="role_StockholdersEquity">
        <link:definition>110 - Statement - Statement of Stockholders Equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsHistoryAndOrganizationTextBlock" id="role_NotesToTheFinancialStatementsHistoryAndOrganizationTextBlock">
        <link:definition>116 - Disclosure - History and Organization</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsBusinessDescriptionAndBasisOfPresentationTextBlock" id="role_NotesToTheFinancialStatementsBusinessDescriptionAndBasisOfPresentationTextBlock">
        <link:definition>117 - Disclosure - Basis of Presentation and Going Concern</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsSignificantAccountingPoliciesTextBlock" id="role_NotesToTheFinancialStatementsSignificantAccountingPoliciesTextBlock">
        <link:definition>118 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsFairValueMeasurementInputsDisclosureTextBlock" id="role_NotesToTheFinancialStatementsFairValueMeasurementInputsDisclosureTextBlock">
        <link:definition>119 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsConvertiblePromissoryNotesAndOtherNotesPayableTextBlock" id="role_NotesToTheFinancialStatementsConvertiblePromissoryNotesAndOtherNotesPayableTextBlock">
        <link:definition>120 - Disclosure - Convertible Promissory Notes And Other Notes Payable</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsLicensingAndCollaborativeAgreementsTextBlock" id="role_NotesToTheFinancialStatementsLicensingAndCollaborativeAgreementsTextBlock">
        <link:definition>121 - Disclosure - Licensing And Collaborative Agreements</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsCommonStockTextBlock" id="role_NotesToTheFinancialStatementsCommonStockTextBlock">
        <link:definition>122 - Disclosure - Common Stock</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsRelatedPartyTransactionsDisclosureTextBlock" id="role_NotesToTheFinancialStatementsRelatedPartyTransactionsDisclosureTextBlock">
        <link:definition>123 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.vistagen.com/taxonomy/role/NotesToTheFinancialStatementsSubsequentEventsTextBlock" id="role_NotesToTheFinancialStatementsSubsequentEventsTextBlock">
        <link:definition>124 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:href="vsta-20111231_cal.xml" xlink:title="Calculation Links, all"/>
      <link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:href="vsta-20111231_def.xml" xlink:title="Definition Links, all"/>
      <link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:href="vsta-20111231_lab.xml" xlink:title="Label Links, all"/>
      <link:linkbaseRef xlink:type="simple" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:href="vsta-20111231_pre.xml" xlink:title="Presentation Links, all"/>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xsd:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xsd:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
  <xsd:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
  <xsd:import namespace="http://fasb.org/us-gaap/2011-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd"/>
  <xsd:import namespace="http://xbrl.sec.gov/dei/2011-01-31" schemaLocation="http://xbrl.sec.gov/dei/2011/dei-2011-01-31.xsd"/>
  <xsd:element name="DocumentandEntityInformationAbstract" id="vsta_DocumentandEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
  <xsd:element name="NotesToTheFinancialStatementsAbstract" id="vsta_NotesToTheFinancialStatementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
  <xsd:element name="NotesPayableAndAccruedInterestToRelatedParties" id="vsta_NotesPayableAndAccruedInterestToRelatedParties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PutOptionAndNoteTermExtensionOptionLiabilities" id="vsta_PutOptionAndNoteTermExtensionOptionLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="NoninterestBearingPromissoryNotes" id="vsta_NoninterestBearingPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="DeferredRevenues" id="vsta_DeferredRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="AccruedInterestOnPromissoryNotes" id="vsta_AccruedInterestOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="NotesPayableAndAccruedInterest" id="vsta_NotesPayableAndAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="NotesPayableAndAccruedInterestToRelatedPartiesNonCurrent" id="vsta_NotesPayableAndAccruedInterestToRelatedPartiesNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="ConvertiblePromissoryNotesNetOfCurrentPortion" id="vsta_ConvertiblePromissoryNotesNetOfCurrentPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="AccruedInterestOnPromissoryNotesNonCurrent" id="vsta_AccruedInterestOnPromissoryNotesNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="AccruedOfficersCompensation" id="vsta_AccruedOfficersCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="AccountsPayableNonCurrent" id="vsta_AccountsPayableNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PreferredStockSeriesA" id="vsta_PreferredStockSeriesA" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="NotesReceivableFromSaleOfCommonStockToOthers" id="vsta_NotesReceivableFromSaleOfCommonStockToOthers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="ConvertiblePromissoryNotes" id="vsta_ConvertiblePromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PreferredStockSeriesAPerOrStatedValuePerShare" id="vsta_PreferredStockSeriesAPerOrStatedValuePerShare" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PreferredStockSeriesASharesAuthorized" id="vsta_PreferredStockSeriesASharesAuthorized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PreferredStockSeriesASharesIssued" id="vsta_PreferredStockSeriesASharesIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="PreferredStockSeriesASharesOutstanding" id="vsta_PreferredStockSeriesASharesOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="NotesReceivableFromSaleOfCommonStock" id="vsta_NotesReceivableFromSaleOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" xbrli:balance="credit"/>
  <xsd:element name="RevenueFromExternalCustomers" id="vsta_RevenueFromExternalCustomers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="credit"/>
  <xsd:element name="AcquiredInProcessResearchAndDevelopment" id="vsta_AcquiredInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ChangeInPutAndNoteExtensionOptionAndWarrantLiabilities" id="vsta_ChangeInPutAndNoteExtensionOptionAndWarrantLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="AmortizationOfImputedDiscountOnNonInterestBearingNotes" id="vsta_AmortizationOfImputedDiscountOnNonInterestBearingNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="AmortizationOfDiscountsOn775And10ConvertibleNotes" id="vsta_AmortizationOfDiscountsOn775And10ConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="AmortizationOfDiscountsOnPlatinumNotes" id="vsta_AmortizationOfDiscountsOnPlatinumNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="AmortizationOfDiscountsOnAugust2010ShortTermNotes" id="vsta_AmortizationOfDiscountsOnAugust2010ShortTermNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ChangeInPutAndNoteTermExtensionOptionAndWarrantLiabilities" id="vsta_ChangeInPutAndNoteTermExtensionOptionAndWarrantLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ExpenseRelatedToModificationOfWarrants" id="vsta_ExpenseRelatedToModificationOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ConsultingServicesByRelatedPartiesSettledByIssuingPromissoryNotes" id="vsta_ConsultingServicesByRelatedPartiesSettledByIssuingPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ProceedsFromIssuanceOf7NotePayableToFoundingStockholder" id="vsta_ProceedsFromIssuanceOf7NotePayableToFoundingStockholder" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOf7ConvertibleNotes" id="vsta_NetProceedsFromIssuanceOf7ConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOf10ConvertibleNotesAndWarrants" id="vsta_NetProceedsFromIssuanceOf10ConvertibleNotesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOfPlatinumNotesAndWarrants" id="vsta_NetProceedsFromIssuanceOfPlatinumNotesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOf20082010NotesAndWarrants" id="vsta_NetProceedsFromIssuanceOf20082010NotesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOf20062007NotesAndWarrants" id="vsta_NetProceedsFromIssuanceOf20062007NotesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="ProceedsFromIssuanceOf7NotesPayable" id="vsta_ProceedsFromIssuanceOf7NotesPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="NetProceedsFromIssuanceOfAugust2010ShortTermNotesAndWarrants" id="vsta_NetProceedsFromIssuanceOfAugust2010ShortTermNotesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" xbrli:balance="debit"/>
  <xsd:element name="HistoryAndOrganizationTextBlock" id="vsta_HistoryAndOrganizationTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
  <xsd:element name="ConvertiblePromissoryNotesAndOtherNotesPayableTextBlock" id="vsta_ConvertiblePromissoryNotesAndOtherNotesPayableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
  <xsd:element name="LicensingAndCollaborativeAgreementsTextBlock" id="vsta_LicensingAndCollaborativeAgreementsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
  <xsd:element name="CommonStockTextBlock" id="vsta_CommonStockTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
</xsd:schema>
</XBRL>
