Pre-Modification [Member]
Short-term Debt, Type [Axis]
Post-Modification [Member]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Hierarchy [Axis]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 3 [Member]
Senior Note1 [Member]
Related Party [Axis]
Senior Note 2 [Member]
Senior Note 3 [Member]
Senior Note 4 [Member]
Senior Note 5 [Member]
Senior NonCurrent [Member]
M F Note B [Member]
M F Note A [Member]
BurrPilgerMayer [Member]
Desjardins [Member]
McCarthyTetrault [Member]
UniversityHealthNote1 [Member]
Service Provider Notes Total [Member]
Service Providers Current [Member]
Service Providers Noncurrent [Member]
Insurance Company [Member]
Vendor [Member]
Vendor Current [Member]
Unrelated Parties [Member]
Unrelated Parties Current [Member]
Unrelated Parties Noncurrent [Member]
Cato Note 1 [Member]
Cato Note 2 [Member]
Related Parties Aggregate [Member]
Related Parties Current [Member]
Related Parties Noncurrent [Member]
Related Parties After Discount [Member]
Service Providers After Discount [Member]
Senior Note Total [Member]
MF Note A [Member]
Service Providers Total [Member]
MF Note B [Member]
Univ Health Note [Member]
Service Note Current [Member]
Service Notes Noncurrent [Member]
Senior Notes Total [Member]
Warrant 1 [Member]
Class of Warrant or Right [Axis]
Warrant 2 [Member]
Warrant 3 [Member]
Warrant 4 [Member]
Warrant 5 [Member]
Warrant 6 [Member]
Warrant 7 [Member]
US NIH [Member]
Type of Arrangement and Non-arrangement Transactions [Axis]
UHN [Member]
Cato [Member]
CBV Note [Member]
CRL Note [Member]
Officer [Member]
Ten Percent Note [Member]
SeniorConvertibleNoteJuly [Member]
PreModification 2 [Member]
PostModification 2 [Member]
PreModification 3 [Member]
PostModification 3 [Member]
Common Stock
Equity Components [Axis]
Additional Paid-In Capital
Treasury Stock
Minimum [Member]
Income Statement Location [Axis]
Maximum [Member]
AntidilutiveNotes1 [Member]
Antidilutive Securities [Axis]
AntidilutiveNotes2 [Member]
AntidilutiveNotes3 [Member]
PreModification4 [Member]
PostModification4 [Member]
Stock Plan 2008 [Member]
Share Based Compensation [Axis]
Stock Plan 1999 [Member]
$8.00 [Member]
Exercise Price Range [Axis]
$10.00 [Member]
$14.40 to $36.00 [Member]
Series A Preferred
Note Receivable from Sale of Stock
Deficit Accumulated During the Development Stage
2014 Unit Proceeds [Member]
2013 Unit Proceeds [Member]
Unit Stock [Member]
Warrant [Member]
Note [Member]
Research and Development Expense [Member]
General and Administrative Expense [Member]
Series B Preferred
SeniorConvertible4 [Member]
Document And Entity Information
Entity Registrant Name
Entity Central Index Key
Document Type
Document Period End Date
Amendment Flag
Current Fiscal Year End Date
Is Entity a Well-known Seasoned Issuer?
Is Entity a Voluntary Filer?
Is Entity's Reporting Status Current?
Entity Filer Category
Entity Public Float
Entity Common Stock, Shares Outstanding
Document Fiscal Period Focus
Document Fiscal Year Focus
Statement of Financial Position [Abstract]
ASSETS
Current assets:
Cash and cash equivalents
Prepaid expenses and other current assets
Total current assets
Property and equipment, net
Security deposits and other assets
Total assets
LIABILITIES AND STOCKHOLDERS' DEFICIT
Current liabilities:
Accounts payable
Accrued expenses
Advance from officer
Current maturities of senior secured convertible promissory notes and accrued interest
Current portion of notes payable, net of discount of $474,500 at March 31, 2014 and accrued interest
Current portion of notes payable to related parties, net of discount of $54,500 at March 31, 2015 and accrued interest
Convertible promissory notes and accrued interest, net of discount of $180,000 at March 31, 2015 and $697,400 at March 31, 2014, respectively
Capital lease obligations
Total current liabilities
Non-current liabilities:
Senior secured convertible promissory notes, net of discount of $0 at March 31, 2015 and $2,085,900 at March 31, 2014, respectively, and accrued interest
Notes payable, net of discount of $0 at March 31, 2015 and $848,100 at March 31, 2014, and accrued interest
Notes payable to related parties, net of discount of $103,200 at March 31, 2014 and accrued interest
Warrant liability
Deferred rent liability
Capital lease obligations
Total non-current liabilities
Total liabilities
Commitments and contingencies
Stockholders' deficit:
Preferred stock, $0.001 par value; 10,000,000 shares, including 500,000 Series A shares, authorized at March 31, 2015 and March 31, 2014, respectively; 500,000 Series A shares issued and outstanding at March 31, 2015 and March 31, 2014, respectively
Common stock, $0.001 par value; 10,000,000 shares authorized at March 31, 2015 and March 31, 2014, respectively; 1,677,110 shares and 1,310,093 shares issued at March 31, 2015 and March 31, 2014, respectively
Additional paid-in capital
Treasury stock, at cost, 135,665 shares of common stock held at March 31, 2015 and March 31, 2014, respectively
Notes receivable from sale of common stock
Accumulated deficit
Total stockholders' deficit
Total liabilities and stockholders' deficit
Statement [Table]
Statement [Line Items]
Current portion of notes payable, net of discount
Current portion of notes payable to related parties, net of discount
Convertible promissory notes and accrued interest
Senior secured convertible promissory notes, net of discount
Notes payable, net of discount
Notes payable to related parties, net of discount
Stockholders deficit:
Preferred Stock, par value
Preferred Stock, Authorized
PreferredStockSeriesASharesIssued
PreferredStockSeriesASharesOutstanding
Common Stock, Par Value Par Share
Common Stock, Shares Authorized
Common Stock, Shares, Issued
Treasury Stock, Shares
Income Statement [Abstract]
Operating expenses:
Research and development
General and administrative
Total operating expenses
Loss from operations
Other expenses, net:
Interest expense, net
Change in warrant liability
Loss on extinguishment of debt
Other expense
Loss before income taxes
Income taxes
Net loss and comprehensive loss
Basic net loss per common share
Diluted net loss per common share
Weighted average shares used in computing basic net loss per common share
Weighted average shares used in computing diluted net loss per common share
Statement of Cash Flows [Abstract]
Cash flows from operating activities:
Net loss
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization
Amortization of discounts on convertible and promissory notes
Change in warrant liability
Stock-based compensation
Expense related to modification of warrants
Non-cash rent and relocation expense
Interest income on note receivable for stock purchase
Loss on settlement of note receivable for stock purchase
Fair value of common stock granted for services
Fair value of warrants granted for services and interest
Gain on currency fluctuation
Loss on extinguishment of debt
Changes in operating assets and liabilities:
Prepaid expenses and other current assets
Security deposits and other assets
Accounts payable and accrued expenses, including accrued interest
Net cash used in operating activities
Cash flows from investing activities:
Purchases of equipment, net
Net cash used in investing activities
Cash flows from financing activities:
Net proceeds from issuance of common stock and warrants, including Units
Proceeds from exercise of modified warrants
Proceeds from sales of notes and warrants to Platinum
Advance from officer
Repayment of capital lease obligations
Repayment of notes
Net cash provided by financing activities
Net increase (decrease) in cash and cash equivalents
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Supplemental disclosure of cash flow activities:
Cash paid for interest
Cash paid for income taxes
Supplemental disclosure of noncash activities:
Insurance premiums settled by issuing note payable
Accounts payable settled by issuance of stock or notes payable and stock
Recognition of warrant liability upon issuance to Platinum of July 2013 Senior Secured Convertible Note
Beginning Balance, Amount
Beginning Balance, Shares
Share-based compensation expense
Proceeds from sale of common stock for cash, including exercises of warrants under Discount Warrant Exercise Program, Amount
Proceeds from sale of common stock for cash, including exercisesof warrants under Discount Warrant Exercise Program, Shares
Beneficial conversion feature on note issued to Platinum in July 2013
Payments on and settlement of note receivable for sale of stock
Allocated proceeds from sale of Units for cash under 2013 Unit Private Placement, including beneficial conversion feature
Allocated proceeds from sale of Units for cash under 2013 Unit Private Placement, including beneficial conversion feature, Shares
Allocated proceeds from sale of Units for cash under 2014 Unit Private Placement, including beneficial conversion feature
Allocated proceeds from sale of Units for cash under 2014 Unit Private Placement, including beneficial conversion feature, Shares
Incremental fair value of warrant modifications
Fair value of warrants issued to Morrison & Foerster, Cato Research Ltd. and University Health Network in connection with accrued interest on underlying notes
Net Loss
Ending Balance, Amount
Ending Balance, Shares
Notes to Financial Statements
Description of Business
Basis of Presentation and Going Concern
Summary of Significant Accounting Policies
Fair Value Measurements
Prepaid Expenses and Other Current Assets
Property, Plant and Equipment [Abstract]
Property and Equipment
Accrued Expenses
Convertible Promissory Notes and Other Notes Payable
Capital Stock
Research and Development [Abstract]
Research and Development Expenses
Income Tax Disclosure [Abstract]
Income Taxes
Licensing and Collaborative Agreements
Text Block [Abstract]
Stock Option Plans and 401(k) Plan
Related Party Transactions
Commitments and Contingencies Disclosure [Abstract]
Commitments, Contingencies, Guarantees and Indemnifications
Subsequent Events
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Supplemental Financial Information
Summary Of Significant Accounting Policies Policies
Basis of Presentation and Going Concern
Use of Estimates
Principles of Consolidation
Cash and Cash Equivalents
Property and Equipment
Impairment or Disposal of Long-Lived Assets
Revenue Recognition
Research and Development Expenses
Stock-Based Compensation
Income Taxes
Concentrations of Credit Risk
Warrant Liability
Comprehensive Loss
Loss per Common Share
Recent Accounting Pronouncements
Summary Of Significant Accounting Policies Tables
Computation of basic net income (loss) and diluted net loss attributable to common stockholders per share
Schedule of antidilutive securities excluded from computation of earnings per share
Fair Value Measurements Tables
Fair value heirarchy for liabilities measured at fair value on a recurring basis
Changes in Level 3 liabilities
Prepaid Expenses And Other Current Assets Tables
Prepaid Expenses
Property and equipment
Accrued Expenses Tables
Accrued Expenses
Convertible Promissory Notes And Other Notes Payable Tables
Convertible Promissory Notes and Other Notes Payable
Capital Stock Tables
Unit Warrant grants and allocation of Proceeds
Black-Scholes Option Pricing Model
Description of units
Shares reserved for future issuance
Provision/benefit computed for income taxes
Components of deferred tax assets
Share-based compensation expense
Black-Scholes option valuation model assumptions for share-based compensation expense
Summary of stock option plan activity
Stock options outstanding and exercisable under Company's option plan
Assets under capital lease obligations
Future minimum payments required under Capital Leases
Future minimum principal payments related to Long-Term Debt
Unaudited Quarterly Results of Operations
Auction Market Preferred Securities, Stock Series [Table]
Auction Market Preferred Securities, Stock Series [Line Items]
Reverse split ratio
Accumulated Deficit during its development stage
Cash proceeds from convertible and short-term notes
Cash proceeds from grant awards and other events
Equity issuance
Cash expenditure
Proceeds from SPAs
Shares issued under SPA
Warrants issued under SPA
Note interest rate
Warrants issued shares
Warrant exercise price
Private placement proceeds
Alternative financing, minimum
Debt converted to preferred stock
Preferred stock issued for conversion of debt
Unit note converted to preferred stock
Preferred stock issued for conversion of note
Warrants issued
Warrant exercise price
Purchase of notes amount
Securities purchase agreement
Securities purchase agreement, shares
Shares issued upon consideration
Warrants issued upon consideration
Common stock exchanged for preferred
Summary Of Significant Accounting Policies Details 1
Numerator:
Net loss attributable to common stockholders for basic earnings per share
less: change in fair value of warrant liability attributable to Exchange, Investment and Bridge Warrants issued to Platinum
Net loss for diluted earnings per share attributable to common stockholders
Denominator:
Weighted average basic common shares outstanding
Assumed conversion of dilutive securities:
Warrants to purchase common stock
Potentially dilutive common shares assumed converted
Denominator for diluted earnings per share - adjusted weighted average shares
Basic net loss attributable to common stockholders per common share
Diluted net loss attributable to common stockholders per common share
Loss per Common Share
Series A preferred stock issued and outstanding
Warrant shares issuable to Platinum upon exchange of Series A Preferred under the terms of the October 11, 2012 Note Exchange and Purchase Agreement
Outstanding options under the 2008 and 1999 Stock Incentive Plans
Outstanding warrants to purchase common stock
Convertible promissory notes and accrued interest
Total
Liabilities, Fair Value Disclosure
Warrant liability
Warrant liability, beginning of period
Recognition of warrant liability during period
Mark to Market gain included in net income
Warrant liability, end of period
Prepaid Expenses And Other Current Assets Details
Prepaid Expenses
Insurance
Legal fees
Interest receivable on note receivable from sale of common stock
Technology license fees and all other
Total
Laboratory equipment
Tenant improvements
Computers and network equipment
Office furniture and equipment
Property and equipment gross
Accumulated depreciation and amortization
Accrued Expenses Details
Accrued Expenses
Accrued professional services
Accrued compensation
All other
Total
Principal Balance
Accrued Interest
Total
Note discount on principal
Note discount on accrued interest
Note discount, total
Warrant shares issued
Market price per share
Exercise price per share
Expected term (years)
Risk-free interest rate
Volatility
Dividend rate
Fair Value per share
Aggregate fair value of unit warrants
Aggregate proceeds of unit sales
Warrants outstanding
Exercise price per share
Expirate date range
Shares subject to purchase
Capital Stock Details 3
Upon exchange of all shares of Series A Preferred Stock currently issued and outstanding
Warrant shares issuable to Platinum upon exercise of common stock warrant upon exchange of Series A preferred stock under the terms of the October 11, 2012 Note Purchase and Exchange Agreement
110% of shares issuable upon conversion of 10% senior secured convertible notes (2)
Pursuant to warrants to purchase common stock:
Subject to outstanding warrants
Issuable pursuant to accrued interest through maturity on outstanding promissory notes issued to Morrison & Foerster, Cato Research Ltd., and University Health Network
Pursuant to warrants to purchase common stock, total
Pursuant to stock incentive plans:
Subject to outstanding options under the 2008 and 1999 Stock Incentive Plans
Available for future grants under the 2008 Stock Incentive Plan
Pursuant to stock incentive plans, total
For additional issuances under the 2014 Private Placement of Units and upon conversion of notes and accrued interest issued to the 2013/ Private Placement of Units and 2014 Private Placement of Units
Total
Research and development expenses
Income Taxes Details
Computed expected tax benefit
Tax effect of Warrant Liabilitiy mark to market
Losses not benefitted
Other
Income tax expense
Income Taxes Details 1
Net operating loss carry-forwards
Basis differences in fixed assets
Accruals and reserves
Total deferred tax assets, net
Valuation allowance
Net deferred tax asset
Valuation allowance increase
U.S. federal net operating loss carryforwards
state net operating loss carryforwards
Monthly research funding payments
Promissory note issuance
Warrant issued with promissory note
Research funding payments
Award upon agreed milestones
Grant revenue
Research and development expenses
Stock option grants
Fully-vested warrants granted to officer and consultants
Warrants granted to officer
Total research and development expense related to stock-based compensation expense
Total stock-based compensation expense
Exercise price
Market price on date of grant
Risk-free interest rate
Expected (years)
Volatility
Fair value per share at grant date
Number of Shares
Options outstanding at beginning of period
Options granted
Options exercised
Options forfeited
Options expired
Options outstanding at end of period
Options exercisable at end of period
Weighted Average Exercise Price
Weighted average exercise price, Options outstanding at beginning of period
Options granted
Options exercised
Options forfeited
Options expired
Weighted average exercise price, Options outstanding at end of period
Weighted average exercise price, Options exercisable at end of period
Weighted average grant-date fair value of options granted during the period
Range [Axis]
Weighted Average Remaining Years until Expiration
ShareBasedCompensationAxis [Axis]
Maximum number of shares granted
Maximum term of 10% or more owners
Maximum term of any other owner
Modification options
Modification charge of options to certain employees
Shares remaining for grant under 2008 Plan
Quoted market price of common stock
Aggregate intrinsic value of outstanding options
Aggregate intrinsic value related to exercisable options
Unrecognized compensation cost
Unrecognized compensation cost related to unvested warrant grants
Proceeds from short-term loan
Interest rate on note
Total interest expense
Incurred expenses on research and subsequent other projects
Estimate accrued of gross-up amount
Warrant price
Repayment of promissory note
Commitments Contingencies Guarantees And Indemnifications Details
Capital lease obligations
Leased laboratory equipment
Leased office equipment
Total lease obligations
Accumulated amortization
Leased laboratory and computer equipment, net
Commitments Contingencies Guarantees And Indemnifications Details 1
Future minimum payment, capital leases, Equipment
Lease payment 2016
Lease payment 2017
Lease payment 2018
Future minimum lease payments
Less imputed interest included in minimum lease payments
Present value of minimum lease payments
Less current portion
Non-current capital lease obligation
Commitments Contingencies Guarantees And Indemnifications Details 2
Future minimum payments, principal
2016
2017
2018
Total
Commitments Contingencies Guarantees And Indemnifications Details 3
Future minimum principal payments related to long-term debt:
2016
2017
2018
2019
Thereafter through June 2019
Total
Facility rent expense
Proceeds from private placement
Note issued
Preferred shares authorized
Preferred conversion price per share
Dividend rate
Preferred shares issued pursuant to note purchase
Warrants issued pursuant to note purchase
Supplemental Financial Information Details
Revenues
Research and development
Total operating expenses
Loss from operations
Interest expense, net
Change in warrant liabilities
Other expense, net
Income (loss) before income taxes
Net income (loss)
Weighted average shares used in computing:
Basic net income (loss) per common share
Diluted net loss per common share
Shares of common stock retroactively reflected as outstanding
Shares held by stockholders, pre-merger
Blackscholes Option Pricing Model Table Text Block.
Custom Element.
Custom Element
Custom Element
Desjardins Member.
Custom Element
Custom Element
Custom Element
Custom Element
Legal Fees1.
Custom Element
Custom Element.
Custom Element.
Custom Element
Custom Element
Custom Element
Notes Payable Discount.
Notes Payable Discount Related Parties.
Custom Element
Outstanding Warrants To Purchase Common Stock.
Custom Element
Custom element.
Custom element.
Prepaid Expenses TableText Block.
Custom Element
Custom Element
Total.
Unrelated Parties Member.
Warrant exercise price.
Assets, Current
Assets
Liabilities, Current
Capital Lease Obligations, Noncurrent
Liabilities, Noncurrent
Liabilities
Stockholders' Equity Attributable to Parent
Liabilities and Equity
ChangeInPutAndNoteTermExtensionOptionAndWarrantLiabilities
Increase (Decrease) in Deferred Charges
Increase (Decrease) in Other Receivables
LossOnEarlyExtinguishmentOfDebt
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Deposit Assets
Net Cash Provided by (Used in) Operating Activities
Payments to Acquire Machinery and Equipment
Net Cash Provided by (Used in) Investing Activities
Repayments of Notes Payable
Net Cash Provided by (Used in) Financing Activities
Cash and Cash Equivalents, Period Increase (Decrease)
Shares, Issued
Basis of Accounting, Policy [Policy Text Block]
Property, Plant and Equipment, Policy [Policy Text Block]
Research and Development Expense, Policy [Policy Text Block]
Income Tax, Policy [Policy Text Block]
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Debt [Table Text Block]
ScheduleofSharebasedCompensationExpenseTextBlock
Class of Warrant or Right, Exercise Price of Warrants or Rights
Earnings Per Share [Abstract]
ConvertiblePromissoryNotesAndAccruedInterest
Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value
Prepaid Expense, Current [Abstract]
Prepaid Expense and Other Assets, Current
Accrued Liabilities, Current [Abstract]
Long-term Debt, Gross
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Exercise Price
Common Stock, Capital Shares Reserved for Future Issuance
FairValueAssumptionsRiskFreeInterestRates
ShareBasedCompensationArrangementByShareBasedPaymentAwardVolatilityRate
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingPeriodIncreaseDecreaseWeightedAverageExercisePrice2
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Capital Lease Obligations [Abstract]
FutureMinimumPrincipalPayments
Long-term Debt, Maturities, Repayments of Principal in Next Rolling Twelve Months
Long-term Debt, Maturities, Repayments of Principal in Rolling Year Two
Long-term Debt, Maturities, Repayments of Principal in Rolling Year Three
Long-term Debt
Preferred Stock, Dividend Rate, Percentage