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<!--Date of creation: 08-12-2021-->
<!--Software architectural design and coding: Dipendra K. Singh-->
<!--Copyright (c) 2021 I-NET Business Solutions, Inc. All Rights Reserved.-->
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  <import namespace="http://fasb.org/srt-roles/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-roles-2020-01-31.xsd" />
  <import namespace="http://fasb.org/srt-types/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-types-2020-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
  <import namespace="http://fasb.org/us-roles/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-roles-2020-01-31.xsd" />
  <import namespace="http://fasb.org/us-types/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-types-2020-01-31.xsd" />
  <import namespace="http://fasb.org/srt/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd" />
  <import namespace="http://fasb.org/us-gaap/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd" />
  <element id="vtgn_SecurityDepositsAndOtherAssets" name="SecurityDepositsAndOtherAssets" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AccruedDividendsNoncurrent" name="AccruedDividendsNoncurrent" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AccruedDividendOnSeriesBPreferredStock" name="AccruedDividendOnSeriesBPreferredStock" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ExpenseRelatedToWriteOffOfDeferredOfferingCosts" name="ExpenseRelatedToWriteOffOfDeferredOfferingCosts" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_IncreaseDecreaseOperatingLeaseLiability" name="IncreaseDecreaseOperatingLeaseLiability" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_InsurancePremiumSettledIssuingNotePayable" name="InsurancePremiumSettledIssuingNotePayable" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AccruedDividendsOnSeriesBPreferred" name="AccruedDividendsOnSeriesBPreferred" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ForCashInPrivatePlacementShares" name="ForCashInPrivatePlacementShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ForCashInPrivatePlacementAmount" name="ForCashInPrivatePlacementAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_PurchasePlanShares" name="PurchasePlanShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_PurchasePlanAmount" name="PurchasePlanAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AccruedDividendsOnSeriesBPreferredStock" name="AccruedDividendsOnSeriesBPreferredStock" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_StockBasedCompensationExpenseIncludingEspp" name="StockBasedCompensationExpenseIncludingEspp" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ProceedsFromExerciseOfWarrantsShares" name="ProceedsFromExerciseOfWarrantsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ProceedsFromExerciseOfWarrantsAmount" name="ProceedsFromExerciseOfWarrantsAmount" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ConversionOfSeriesDPreferredStockIntoCommonStockShares" name="ConversionOfSeriesDPreferredStockIntoCommonStockShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ConversionOfSeriesDPreferredStockIntoCommonStockAmount" name="ConversionOfSeriesDPreferredStockIntoCommonStockAmount" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_IssuanceOfCommonStockUponCashlessExerciseOfOptionsShares" name="IssuanceOfCommonStockUponCashlessExerciseOfOptionsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_IssuanceOfCommonStockUponCashlessExerciseOfOptionsAmount" name="IssuanceOfCommonStockUponCashlessExerciseOfOptionsAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ReceivableFromSupplierDisclosureTextBlock" name="ReceivableFromSupplierDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_PrepaidAndOtherAssetsDisclosureTextBlock" name="PrepaidAndOtherAssetsDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AssetsSubjectToFinancingLease" name="AssetsSubjectToFinancingLease" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_OtherLeaseDisclosureTableTextBlock" name="OtherLeaseDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateOfferingPriceDescription" name="AggregateOfferingPriceDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ExerciseOfOutstandingWarrants" name="ExerciseOfOutstandingWarrants" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateSharesOfCommonStock" name="AggregateSharesOfCommonStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateSharesOfCommonStockAmount" name="AggregateSharesOfCommonStockAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AdditionallySharesOptionsGranted" name="AdditionallySharesOptionsGranted" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AdditionallySharesOptionsGrantedAmount" name="AdditionallySharesOptionsGrantedAmount" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_UpfrontLicensePayment" name="UpfrontLicensePayment" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_CashAndCashEquivalents" name="CashAndCashEquivalents" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_MarketPricePerShareAtGrantDate" name="MarketPricePerShareAtGrantDate" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ExercisePricePerShare" name="ExercisePricePerShare" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_SharesPortion" name="SharesPortion" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_SublicenseFees" name="SublicenseFees" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_UnregisteredCommonStockIssuedForAcquisitionCostsValue" name="UnregisteredCommonStockIssuedForAcquisitionCostsValue" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_OptionVestedPercentage" name="OptionVestedPercentage" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ClinicalAndNonclinicalMaterialsAndContractServices" name="ClinicalAndNonclinicalMaterialsAndContractServices" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AllOtherPrepaids" name="AllOtherPrepaids" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AccruedDevelopmentExpenses" name="AccruedDevelopmentExpenses" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ExpirateDateRange" name="ExpirateDateRange" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ShareBasedCompensationArrangementByShareBasedPaymentAwardWarrantsExercisableNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardWarrantsExercisableNumber" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_UnregisteredSharesOfCommonStockSold" name="UnregisteredSharesOfCommonStockSold" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_InitialPurchaseOfCommonStock" name="InitialPurchaseOfCommonStock" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_RegisteredSharesOfCommonStockSold" name="RegisteredSharesOfCommonStockSold" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateGrossCashProceeds" name="AggregateGrossCashProceeds" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_IntialOfferingPriceAggregateAmount" name="IntialOfferingPriceAggregateAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_CommissionPercentUponSales" name="CommissionPercentUponSales" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateSharePurchaseOfCommonStock" name="AggregateSharePurchaseOfCommonStock" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_OptionToPurchaseSharesOfCommonsShares" name="OptionToPurchaseSharesOfCommonsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AggregateSharesIssuedOfCommonStockShares" name="AggregateSharesIssuedOfCommonStockShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_EsppPurchaseShareOfCommonStock" name="EsppPurchaseShareOfCommonStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ProceedRecievedUnderEspp" name="ProceedRecievedUnderEspp" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_WeightedAverageExercisePrice" name="WeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_WarrantsDescription" name="WarrantsDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_RightOfUseAssetOperatingLease" name="RightOfUseAssetOperatingLease" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_AssumedRemainingLeaseTermInYears" name="AssumedRemainingLeaseTermInYears" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities" name="CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_OperatingLeaseCostCurrent" name="OperatingLeaseCostCurrent" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_PerformanceObligations" name="PerformanceObligations" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_ExerciseOfWarrantsShares" name="ExerciseOfWarrantsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="vtgn_PurchaseOfOptions" name="PurchaseOfOptions" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element name="TwoThousandNineteenPlanMember" id="vtgn_TwoThousandNineteenPlanMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="AffaMedAgreementMember" id="vtgn_AffaMedAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ContractLiabilitiesCurrentMember" id="vtgn_ContractLiabilitiesCurrentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ContractLiabilitiesNonCurrentMember" id="vtgn_ContractLiabilitiesNonCurrentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="DeferredContractAcquisitionCostsCurrentMember" id="vtgn_DeferredContractAcquisitionCostsCurrentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="DeferredContractAcquisitionCostsNonCurrentMember" id="vtgn_DeferredContractAcquisitionCostsNonCurrentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Plan2019Member" id="vtgn_Plan2019Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="LaboratoryEquipmentMember" id="vtgn_LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="TwoThousandSixteenEquityIncentivePlanAndTwoThousandNinteenPlanMember" id="vtgn_TwoThousandSixteenEquityIncentivePlanAndTwoThousandNinteenPlanMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="TenantImprovementsMember" id="vtgn_TenantImprovementsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ManufacturingEquipmentMember" id="vtgn_ManufacturingEquipmentMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="WarrantsMember" id="vtgn_WarrantsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PH94BMember" id="vtgn_PH94BMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="TwoThousandNineteenEmployeeStockPurchasePlanMember" id="vtgn_TwoThousandNineteenEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant1Member" id="vtgn_Warrant1Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant2Member" id="vtgn_Warrant2Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant3Member" id="vtgn_Warrant3Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant4Member" id="vtgn_Warrant4Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant5Member" id="vtgn_Warrant5Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant6Member" id="vtgn_Warrant6Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant7Member" id="vtgn_Warrant7Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="Warrant8Member" id="vtgn_Warrant8Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PurchaseAgreementMember" id="vtgn_PurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="LincolnParkCapitalFundMember" id="vtgn_LincolnParkCapitalFundMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="DecemberTwentyTwentyMember" id="vtgn_DecemberTwentyTwentyMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="OpenMarketSaleAgreementMember" id="vtgn_OpenMarketSaleAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="MayTwentyTwentyOneMember" id="vtgn_MayTwentyTwentyOneMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="UnderwritingAgreementMember" id="vtgn_UnderwritingAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ConstructionsMember" id="vtgn_ConstructionsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="OmnibusEquityIncentivePlanMember" id="vtgn_OmnibusEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="EmployeesMember" id="vtgn_EmployeesMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="April2021Member" id="vtgn_April2021Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="MarketSaleAgreementMember" id="vtgn_MarketSaleAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="JefferiesLLCMember" id="vtgn_JefferiesLLCMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
</schema>
