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  <xsd:element id="vtgn_StockIssuedDuringPeriodSharesStockOptionsExercisedForCash" name="StockIssuedDuringPeriodSharesStockOptionsExercisedForCash" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockIssuedDuringPeriodSharesStockOptionsExercisedNet" name="StockIssuedDuringPeriodSharesStockOptionsExercisedNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockIssuedDuringPeriodSharesWarrantsExercised" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockIssuedDuringPeriodValueCashlessStockOptionsExercised" name="StockIssuedDuringPeriodValueCashlessStockOptionsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockIssuedDuringPeriodValueSettlementOfLiabilities" name="StockIssuedDuringPeriodValueSettlementOfLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockIssuedDuringPeriodValueWarrantsExercised" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockPurchaseAgreementMaximumValueOfCommittedShares" name="StockPurchaseAgreementMaximumValueOfCommittedShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockPurchaseAgreementPurchasePeriod" name="StockPurchaseAgreementPurchasePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockSalesAgreementCommissionOnSharesSoldPercentage" name="StockSalesAgreementCommissionOnSharesSoldPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_StockSalesAgreementMaximumAggregateOfferingPrice" name="StockSalesAgreementMaximumAggregateOfferingPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_SublicenseFees" name="SublicenseFees" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_SupportToDevelopmentOfPh94bPh10AndAv101Member" name="SupportToDevelopmentOfPh94bPh10AndAv101Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_TenantImprovementsMember" name="TenantImprovementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_The2016EquityIncentivePlanMember" name="The2016EquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_The2019EmployeeStockPurchasePlanMember" name="The2019EmployeeStockPurchasePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_The2019OmnibusEquityIncentivePlanMember" name="The2019OmnibusEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_The2020DecemberPublicOfferingMember" name="The2020DecemberPublicOfferingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="vtgn_UpfrontLicensePayment" name="UpfrontLicensePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_VestingAfterFirstAnniversaryMember" name="VestingAfterFirstAnniversaryMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_VestingOverThreeYearsMember" name="VestingOverThreeYearsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_VestingPeriodFirstAnniversaryMember" name="VestingPeriodFirstAnniversaryMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringDecember312022Member" name="WarrantsExpiringDecember312022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringDecember92022Member" name="WarrantsExpiringDecember92022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringFebruary2022ThroughDecember2022Member" name="WarrantsExpiringFebruary2022ThroughDecember2022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringJuly252025Member" name="WarrantsExpiringJuly252025Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringMarch32023Member" name="WarrantsExpiringMarch32023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringMarch72023Member" name="WarrantsExpiringMarch72023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_WarrantsExpiringOctober52022Member" name="WarrantsExpiringOctober52022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-costs-details" name="statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-details" name="statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-minimum-payments-details" name="statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-minimum-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-other-disclosures-details" name="statement-statement-note-10-commitments-and-contingencies-schedule-of-operating-lease-other-disclosures-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-10-commitments-and-contingencies-tables" name="statement-statement-note-10-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-changes-in-contract-liabilities-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-changes-in-contract-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-contract-acquisition-costs-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-contract-acquisition-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-fair-value-of-options-granted-blackscholes-option-pricing-model-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-fair-value-of-options-granted-blackscholes-option-pricing-model-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-excluded-from-earnings-per-share-computation-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-excluded-from-earnings-per-share-computation-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-stockbased-compensation-expense-details" name="statement-statement-note-3-summary-of-significant-accounting-policies-schedule-of-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-3-summary-of-significant-accounting-policies-tables" name="statement-statement-note-3-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-5-prepaid-expenses-and-other-current-assets-schedule-of-prepaid-expenses-and-other-current-assets-details" name="statement-statement-note-5-prepaid-expenses-and-other-current-assets-schedule-of-prepaid-expenses-and-other-current-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-5-prepaid-expenses-and-other-current-assets-tables" name="statement-statement-note-5-prepaid-expenses-and-other-current-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-6-property-and-equipment-schedule-of-assets-subject-to-financing-lease-details" name="statement-statement-note-6-property-and-equipment-schedule-of-assets-subject-to-financing-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-6-property-and-equipment-schedule-of-property-and-equipment-details" name="statement-statement-note-6-property-and-equipment-schedule-of-property-and-equipment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-6-property-and-equipment-tables" name="statement-statement-note-6-property-and-equipment-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-7-accrued-expenses-schedule-of-accrued-expenses-details" name="statement-statement-note-7-accrued-expenses-schedule-of-accrued-expenses-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-7-accrued-expenses-tables" name="statement-statement-note-7-accrued-expenses-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-8-capital-stock-schedule-of-warrants-details" name="statement-statement-note-8-capital-stock-schedule-of-warrants-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-note-8-capital-stock-tables" name="statement-statement-note-8-capital-stock-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="vtgn_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
