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Bold opportunities to change the course of mental health care.

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Fasedienol (PH94B) Publications

Liebowitz, M.R., Hanover, R., Draine, A., Careri, J., Monti, L., Smith, M., Moran, M., & Burnetta, D. (2019). Effect of As‐Needed Use of Intranasal PH94B on Social and Performance Anxiety in Individuals with Social Anxiety Disorder. 2019 Anxiety and …

March 12, 2019

Liebowitz MR, Hanover R, Draine A, Lemming R, Careri J, Monti L (2016). Effect of as‐needed use of intranasal PH94B on social and performance anxiety in individuals with social anxiety disorder. Depress Anxiety 33: 1081-1089.

August 25, 2016

The Pharmaceutical Journal, August 2016, Vol 297, No 7892, online | DOI: 10.1211/PJ.2016.20201479

August 4, 2016

Liebowitz, MR, Monti, L, Hanover, R, Grosser, B (2014) A rapidly acting intranasal treatment for the symptoms of GAD; 2014 ASCP Annual Meeting (formerly NCDEU) Poster Session

June 16, 2014

Liebowitz, MR, Salman, E, Nicolini, H, Rosenthal, N, Hanover, R, Monti. L (2014). Effect of an acute intranasal aerosol dose of PH94B on social and performance anxiety in women with social anxiety disorder. Am. J. Psychiatry 171:675-682.

June 6, 2014

Yager, J, Intranasal Pherines for Social Anxiety Disorder?; NEJM Journal Watch, 2014; 20:6.

April 18, 2014

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Itruvone (PH10) Publications

Monti, L., Smith, M., & Hanover, R. (2022). PH10: A new intranasal neuroactive steroid with rapid onset of antidepressant effect but a mechanism of action different from GABA‐A allosteric modulator antidepressants. Anxiety and Depression Association of Am

March 19, 2022

Monti, L., & Liebowitz, M. (2020). Neural Circuits of Anxiolytic and Antidepressant Pherine Molecules. CNS Spectrums, 1-36. doi:10.1017/S109285292000190X

October 23, 2020

Monti, L., Nicolini, H., Liebowitz, M., & Hanover, R. (2019). “A Placebo Controlled Trial of PH10: Test of a New Rapidly Acting Intranasally Administered Antidepressant.” Br J Phar Med Res 4(6): 2157-2168.

November 13, 2019

Jancin, B. Novel intranasal antidepressant shows results after 1 week; Clinical Psychiatry News, Jun 20 2013.

June 20, 2013

PH10 May be a new rapidly acting Intranasally administered antidepressant; New Clinical Drug Evaluation Unit (NCDEU), 2013: 35-36.

May 28, 2013

PH80 Publications

Monti, L., Baker, R., et. al. (2023). A Phase 2A Clinical Study to Investigate the Efficacy, Safety, and Tolerability of PH80 for the Acute Management of Menopausal Vasomotor Symptoms (Hot Flashes) in Women. Neuroscience Education Institute (NEI) Annual

November 10, 2023

AV-101 Publications

Bourque, M., Grégoire, L., Patel, W., Dickens, D., Snodgrass, R., & Di Paolo, T. (2022). AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys. Cells, 11(22), 3530.

November 8, 2022

Abbasi J. Ketamine Minus the Trip: New Hope for Treatment-Resistant Depression. JAMA. Published online November 08, 2017. doi:10.1001/jama.2017.12975

November 28, 2017

Wallace, M., et al. (2017) “Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of L-4-chlorokynurenine in healthy volunteers.” Scandinavian Journal of Pain…

October 1, 2017

Yaksh, T.L., et al. (2017). “Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.” The Journal of Pain 18: 1184-1196.

April 18, 2017

Gerhard, D. M., et al. (2016) "Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity." Drug Discov Today 21:454-464

March 16, 2016

Li, C., et. al. (2016) “Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid.” Brain Research 1630:73-82

January 1, 2016

Zanos, P., et al. (2015) "The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition." J Pharmacol Exp Ther 355:76-85

July 29, 2015

Bay-Richter, C., et al. (2015) "A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality." Brain Behav Immun 43:110-117

January 1, 2015

Murrough, J. W., et al. (2013) "Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial." Am J Psychiatry 170:1134-1142

October 1, 2013

Schwarcz, R., et al. (2012) "Kynurenines in the mammalian brain: when physiology meets pathology." Nat Rev Neurosci 13:465-477

July 1, 2013

Zarate, C. A., Jr., et al. (2006) "A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression." Arch Gen Psychiatry 63:856-864

August 1, 2006

Kemp, J. A., et al. (1988). "7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex." Proc Natl Acad Sci USA 85:6547-6550.

May 16, 1988

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