Suicidal ideation (suicidal thoughts and behavior) is complex and there is no single cause. People of all genders, ages, and ethnicities can be at risk for suicide. The U.S. National Institute of Mental Health (NIMH) attributes many different factors to someone having suicidal thoughts or making a suicide attempt, including, among other factors, depression, other mental health disorders or substance abuse disorder. Additionally, according to reports released by the U.S. Department of Veterans Affairs, the U.S. Military Veteran population is at significantly higher risk for suicide.
According to the World Health Organization (WHO), every year approximately 800,000 people worldwide take their own life and many more attempt suicide. The CDC views suicide as a major public health concern in the U.S. as rates of suicide have been increasing for both men and women and across all age groups. Suicide is now the 10th leading cause of death in the U.S. and is one of just three leading causes that are on the rise.
We are collaborating with Baylor College of Medicine and the U.S. Department of Veterans Affairs on a Phase 1b clinical trial of AV-101 involving healthy volunteer U.S. Military Veterans from either Operation Enduring Freedom, Operation Iraqi Freedom or Operation New Dawn. The study is a randomized, double-blind, placebo-controlled cross-over study designed as a first-step target engagement study in our plans to test potential anti-suicidal effects of AV-101 in U.S. Military Veterans. Government funding from the U.S. Department of Veterans Affairs is being provided for substantially all other study costs.