Developing New Generation Medicines for Depression and Other Central Nervous System (CNS) Disorders

AV-101 is an orally available new generation prodrug candidate in Phase 2 development, initially for the adjunctive treatment of major depressive disorder (MDD) in patients with an inadequate response to standard, FDA-approved antidepressant therapies.

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Going Above and Beyond Current Treatment Options

Focused on providing novel solutions for millions of depression patients with inadequate response to standard FDA-approved antidepressants

About us

Committed to Advancing a New Generation of Oral Antidepressants

AV-101, an NMDA receptor glycine-binding (GlyB) site antagonist, is a new generation oral antidepressant drug candidate in Phase 2 development, initially for the adjunctive treatment of major depressive disorder (MDD) in patients with an inadequate response to standard FDA-approved antidepressant therapies, which consist primarily of commonly prescribed selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) approved by the U.S. Food and Drug Administration (FDA), as well as atypical antipsychotics (such as aripiprazole) often administered with them, adjunctively. Orally-available AV-101 is a new generation drug candidate for MDD with a mechanism of action that is similar to that of ketamine, and fundamentally differentiated from all FDA-approved antidepressant therapies.

VistaGen Therapeutics, Inc. Pipeline
What Makes AV-101 Different?

Going Above and Beyond Current Treatment Options

Focused on providing novel solutions for millions of depression patients with inadequate response to standard FDA-approved antidepressants.

Learn More About Ketamine and AV-101

Backed by an Experienced Leadership Team

Our highly experienced Management Team, Board of Directors, and CNS Clinical and Regulatory Advisory Board have a proven track record of developing innovative medicines to treat a wide range of CNS diseases and disorders.

Meet Our Team

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